ANTI-SERPINF2 (RABBIT POLYCLONAL) (C005B-241725)

General description

Serpin F2, also known as Alpha-2-antiplasmin Alpha-2-AP, Alpha-2-plasmin inhibitor, Alpha-2-PI, and encoded by the gene name SERPINF2, AAP, or PLI, is a member of the Serpin family. Serpin F2 is a serine protease inhibitor. As an inhibitor, the major targets of Serpin F2 are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Serpin F2 forms protease inhibiting heterodimer with TMPRSS7. Serpin F2 is expressed by the liver and secreted in plasma. Mutations in Serpin F2 have been associated with Alpha-2-plasmin inhibitor deficiency (APLID), an autosomal recessive disorder resulting in severe hemorrhagic diathesis.

Immunogen

Epitope: Alpha-2-antiplasmin mature chain

KLH-conjugated linear peptide corresponding to the Alpha-2-antiplasmin mature chain of human Serpinf2.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Serpinf2 in human liver and human liver cancer tissue.

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

This Anti-Serpinf2 antibody is validated for use in WB, IH for the detection of Serpinf2.

Quality

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Serpinf2 in 10 µg of human liver tissue lysate.

Target description

~73 kDa observed. Predicated to work with both glycos and non-glycos isoforms.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human. species reactivity (predicted by homology): primate (based on 100% sequence homology). technique(s): immunohistochemistry: suitable, western blot: suitable. NCBI accession no.: NP_000925. UniProt accession no.: P08697. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... SERPINF2(5345). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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