Anti-SIRT4 Antibody (C15-1317-229)

General description

NAD-dependent protein deacetylase sirtuin-4 (SIRT4) is also called NAD-dependent ADP-ribosyltransferase sirtuin-4 and SIR2-like protein 4 (SIR2L4). SIRT4 catalyzes the transfer of ADP-ribosyl groups onto target proteins, and has been shown to inhibit GLUD1 enzyme activity, down-regulate insulin secretion and is involved in chromatin silencing. SIRT4 is believed to be a transcriptional regulator in embyonic stem cell and hematopoietic stem cells. SIRT4 is widely expressed and has been detected in vascular smooth muscle and striated muscle, and pancreatic (islets of Langerhans) insulin-producing beta-cells.

Specificity

This antibody is predicted to not cross-react with other Sirtuin family members.

Immunogen

Epitope: N-terminus

KLH-conjugated synthetic peptide corresponding to the N-terminus of human SIRT4.

Application

Anti-SIRT4 Antibody detects level of SIRT4 & has been published & validated for use in SIRT4.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Cell Cycle, DNA Replication & Repair

Quality

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected SIRT4 in human liver tissue lysate.

Target description

~38 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: human. technique(s): western blot: suitable. UniProt accession no.: Q9Y6E7. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... SIRT4(23409). Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.