General description
SLIT and NTRK-like family 4 (Slitrk4) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk4 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth.
Specificity
This antibody recognizes the C-terminus of Slitrk4.
Immunogen
KLH-conjugated linear peptide corresponding to human Slitrk4.
Application
Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected Slitrk4 in human brain tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
This Slitrk4 antibody is validated for use in WB & IHC for the detection of the Slitrk4 protein.
Quality
Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Slitrk4 in 15 µg of mouse brain tissue lysate.
Target description
~94 kDa observed
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Mouse brain tissue lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: mouse, human. technique(s): immunohistochemistry: suitable, western blot: suitable. UniProt accession no.: Q8IW52. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... SLITRK4(139065). Storage Class Code: 10 - Combustible liquids. WGK: WGK 1.- UPC:
- 41116126
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- ABN338