General description
Sex determining region Y (SRY)-box 11 (SOX11) protein belongs to the SRY-related high mobility group (HMG)-box (SOX) family of transcription factors. This protein is localized in adult immature neurons but is normally not expressed in any other adult tissue. SOX11 gene is located on the human chromosome 2p25.2.
Specificity
Anti-SOX11 (C-terminal) recognizes human and rat SOX11.
Immunogen
peptide corresponding to the C-terminal region of human SOX11, conjugated to KLH. The corresponding sequence is identical in monkey, bovine and pig and differs by a single amino acid in mouse and rat.
Application
Anti-SOX11 (C-terminal) antibody produced in rabbit may be used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
Biochem/physiol Actions
Sex determining region Y (SRY)-box 11 (SOX11) plays a role in the regulation of tissue remodeling during embryogenesis which is essential for neurogenesis. This protein is also involved in tumorigenesis. SOX11 protein also plays a role in the determination of cell fate. Upregulation of the SOX11 gene leads to ovarian cancer, brain tumor, medulloblastomas and gliomas. This protein functions as a biomarker in mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL) and Burkitt lymphomas (BL).
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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- UPC:
- 51181912
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SAB4200450-200UL
- Temperature Control Device:
- Yes
