General description

Transcription factor SOX-2 (SOX-2) is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. When SOX-2 is expressed in self renewing progenitor cells, it acts to inhibit neuronal differentiation. Conversely, active repression of SOX-2 induces neural differentiation.

Specificity

Rabbit polyclonal anti-SOX2 antibody recognizes human, mouse, rat sex-determining region Y-box 2 transcription factors.

Immunogen

synthetic peptide corresponding to residues 32-47 of human SOX2.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Western Blotting (1 paper)

Rabbit polyclonal anti-SOX2 antibody is used to tag solute sex-determining region Y-box 2 transcription factor for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques, such as immunoblotting (~37 kDa) and flow cytometry. It is used as a probe to determine the presence and roles of sex-determining region Y-box 2 transcription factor in progenitor cell self renewal and differentiation.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.