General description
SP6 (sp6 transcription factor), also called as KLF14 (kruppel-like factor 14) or Epfn (epiprofin) belongs to SP/KLF (kruppel-like factor) transcription factor family. The protein is encoded by maternally inherited intronless gene, mapped to human chromosome 17q21.3-q22.
KLF14 transcription factor is predominantly expressed in fetal tissues and placenta than in adult tissues. The encoded protein consists of three C2H2-type zinc-fingers attached to each other by kruppel-links at the end of the carboxy-terminal domain and transactivation/suppressor domain at the end of the N-terminal domain.
Immunogen
Sp6 transcription factor recombinant protein epitope signature tag (PrEST)
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Biochem/physiol Actions
SP6 (sp6 transcription factor) might be involved in regulation of transcription process. In mice, SP6 or Epfn (Epiprofin) is involved in epidermal development.
TGF (transforming growth factor)-β treatment upregulates SP6 or KLF14 (Kruppel-like factor 14), which is a vital non-smad protein that potentially represses the transforming growth factor-β receptor II (TGF-βRII). SP6 aids in tooth development by regulating the epithelial cell fate and tooth number.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST75965.
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Shipping Information:
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- UPC:
- 42241516
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- HPA024516-100UL
- Temperature Control Device:
- Yes
