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ANTI-SPG11 ANTIBODY PRODUCED IN CHICKEN

Sigma Aldrich

Catalog No.
C15-1741-422
Manufacturer No.
SAB3500003-100UG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
EA
Price: $894.39
List Price: $993.76

Immunogen SPG11 antibody was raised against a 15 amino acid peptide of human SPG11. Features and Benefits Evaluate our antibodies with complete peace of mind.

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Immunogen

SPG11 antibody was raised against a 15 amino acid peptide of human SPG11.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage. It is expressed in all structures of the brain, with a high expression in the cerebellum. SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene.  Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500003.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

UPC:
12352203
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
SAB3500003-100UG
Product Size:
100/µG

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