ANTI-SUMO-2 ANTIBODY PRODUCED IN RABBIT AFFINITY ISOLATED ANTIBODY BUFFERED AQUEOUS SOLUTION

General description

Small ubiquitin-related modifier (SUMO-2) gene is mapped to human chromosome 17q25.1. Sumo-2 is related to SUMO-3 with a 86% sequence identity. It comprises a sumoylation motif at the residue lysine 11.

Specificity

Anti-SUMO-2 recognizes human SUMO-2.

Immunogen

synthetic peptide corresponding to amino acids 80-93 located at the C-terminal of human SUMO-2, conjugated to KLH. This sequence is identical in many species including rat, mouse, pig, and bovine SUMO-2 and is identical in human SUMO-3.

Application

Anti-SUMO-2 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Small ubiquitin-related modifier (SUMO-2) is essential for the cellular defense in hyperthermic cytotoxicity. Along with SUMO-3, SUMO2 is essential for cell survival post-heat shock. SUMO-2 has the ability to exist as self-modified polymers. SUMO-2 and SUMO-3 negatively regulate interferon induction.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 1% bovien serum albumin and 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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