ANTI-SUN2 ANTIBODY (C005B-241840)

General description

SUN domain-containing protein 2 (SUN2), or Protein UNC-84 homolog B (UNC84B), is a single-pass nuclear envelope transmembrane protein responsible for nuclear migrations that are essential for development. SUN2 has a predicted transmembrane domain and a C-terminal region with similarity to the S. pombe spindle pole body protein Sad1. SUN2 interacts with RAB5A and is widely expressed, and highly expressed in the heart, lungs and muscles. UNC-84 may function to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage.

Immunogen

Epitope: N-terminus

Linear peptide corresponding to the N-terminus of human Sun2.

Application

Detect SUN2 using this Anti-SUN2 antibody validated for use in western blotting & ICC.

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

Western Blotting Analysis: A 1:500 dilution from a representative lot detected SUN2 in 10 µg of A431, Jurkat, L6, and NIH/3T3 cell lysate.
Western Blotting Analysis: A representative lot detected SUN2 recombinant protein (Haque, F., et al. (2010). Journal of Biol. Chem. 285(5): 3487-3498).
Immunocytochemistry Analysis: A representative lot detected SUN2 in human foreskin fibroblasts and NIH/3T3 cells (Haque, F., et al. (2010). Journal of Biol. Chem. 285(5): 3487-3498).

Quality

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected SUN2 in 10 µg of HEK293 cell lysate.

Target description

~ 78 kDa observed. Uncharacterized band(s) may appear in some lysates.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: mouse, human. technique(s): immunocytochemistry: suitable, western blot: suitable. NCBI accession no.: NP_001186508. UniProt accession no.: Q9UH99. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... SUN2(25777). Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

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