ANTI-SYNDECAN4 ANTIBODY PRODUCED IN RABBIT

General description

The SDC-4 (syndecan-4) gene encodes a membrane-spanning proteoglycan which can bear heparan sulfate and chondroitin sulfate chains. Syndecan-4 is predominantly expressed on smooth muscle cells, epithelial cells and cardiomyocytes. The SDC-4 gene is mapped to human chromosome 20q13.12. Anti-Syndecan4 antibody detects endogenous levels of total syndecan-4 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Syndecan4.

Immunogen Range: 145-194

Biochem/physiol Actions

Syndecan-4 (SDC-4) is associated with bone development and osteogenesis by regulating fibroblast growth factor-2 (FGF2). SDC-4 gene expression promotes cell division, migration and adhesion. It is essential for wound healing and takes part in inflammation and fibrosis. An abnormal SDC-4 expression is observed in response to stress and metastatic tumor. Growth factors such as FGF2, TNF-α (tumor necrosis factor α) and TGF-β (transforming growth factor β) also tend to alter SDC-4 expression. It is implicated as a biomarker in cardiovascular disease.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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