ANTI-SYNE2 ANTIBODY PRODUCED IN RABBIT (C15-1460-221)

General description

Spectrin repeat containing nuclear envelope protein 2 (SYNE2) was formerly known as nuclear envelope spectrin repeat protein (Nesprin-2), NUANCE and KASH (is an acronym for Klarsicht, ANC-1, Syne Homology) domain containing protein 2. The gene SYNE2 is localised on human chromosome on 14q23.2.

Immunogen

spectrin repeat containing, nuclear envelope 2

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Anti-SYNE2 antibody recognises SYNE2 protein.

Biochem/physiol Actions

Spectrin repeat containing nuclear envelope protein 2 (SYNE2) is involved in nuclear positioning in the multi-nucleated skeletal muscles in the early developmental stage. SYNE2 is a part of the linker of nucleoskeleton and cytoskeleton (LINC) complex and is essential for connecting the nucleus to the cytoskeleton and other organelles. SYNE2 complexes with SUN2 of SUN proteins (Sad1 and UNC-84) and binds to F-actin to form transmembrane actin-associated nuclear (TAN) lines for actin-dependent nuclear movement. SYNE2 as a KASH domain protein, is involved in nuclear anchorage and migration. SYNE2 is essential for normal development of retina. Mutations in SYNE2 may cause retinal problems in photoreceptors, secondary neurons and muller glia. SYNE2 facilitates ciliogenesis in humans, which is necessary for numerous functions in the human including determining the left and right handedness.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST87551.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.