ANTI-SYPL2 ANTIBODY PRODUCED IN RABBIT (C005B-328074)

General description

Synaptophysin-like 2 (SYPL2) is part of the synaptophysin family and is localized to synaptic vesicles. It is expressed in the heart, brain and kidneys. The gene encoding this protein is localized on human chromosome 1.

Immunogen

SYPL2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human SYPL.

Biochem/physiol Actions

Synaptophysin-like 2 (SYPL2) may be a Ca²⁺-dependent transporter involved in exocytosis. It has been shown to be expressed in activated astrocytes which are linked to senile plaques in individuals with Alzheimer′s disease. Thus, it has been speculated as a protein leading to enhanced neurodegeneration. SYPL2 has been linked to morbid obesity.

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Target description

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores. At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500069.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

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