General description

Anti-Telomerase Antibody detects endogenous levels of total Telomerase protein.

The TERT (telomerase reverse transcriptase) gene is mapped to human chromosome 5p15.33 and encodes for a ribonucleoprotein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Telomerase.

Immunogen Range: 796-845

Biochem/physiol Actions

TERT (telomerase reverse transcriptase) catalyzes the de novo synthesis of telomere and results in cellular immortalization to maintain chromosomal stability. Mutations in TERT causes different types of malignancies such as gliomas, gastric cancer, and anaplastic thyroid cancer. Therefore, TERT serves as an early prognostic biomarker.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.