Anti-Thyroid Hormone Receptor beta-1 Antibody (C15-1317-519)

General description

Thyroid hormone receptor β-1 operates as a hormone-dependent transcriptional regulator that binds DNA sequences and is activated by 3,5,3’-l-triiodothyronine (T3). Thyroid hormone receptor β-1 is important in vertebrate development, specifically in developing limbs and face. 9-cis-retinoic acid receptor (RXR) and retinoic acid receptor (RAR) receptor families are often associated with thyroid hormone receptor β-1 and form homodimers and heterodimers. Mutations in thyroid hormone receptor β-1 have been associated with general resistance to thyroid hormones which tend to cause significant behavioral abnormalities. Recent research has linked thyroid hormone receptor β-1 to tumor suppression, where the receptor has commonly been found to be disrupted in the occurrence of cancer.

Immunogen

KLH-conjugated linear peptide corresponding to human Thyroid Hormone receptor β-1.

Application

Anti-Thyroid Hormone Receptor β-1 Antibody is a rabbit polyclonal antibody for detection of Thyroid Hormone Receptor β-1 also known as Thyroid hormone receptor beta, c-erbA-2, c-erbA-beta & has been validated in WB.

Research Category
Neuroscience

Research Sub Category
Hormones & Receptors

Quality

Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Thyroid Hormone receptor β-1 on 10 µg of HeLa nuclear extract.

Target description

~60 kDa observed. An uncharacterized band may be observed at ~45 kDa in some lysates.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
HeLa nuclear extract

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. purified by: affinity chromatography. species reactivity: mouse, human. species reactivity (predicted by homology): rat (based on 100% sequence homology). technique(s): western blot: suitable. NCBI accession no.: NP_000452. UniProt accession no.: P10828. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: human ... THRB(7068). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.