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ANTI-TICAM1/TRIF (AB1) ANTIBODY PRODUCED IN RABBIT

Catalog No.
C005B-328194
Mfr. No.
SAB2900288-50UG
Mfr. Name
Sigma-Aldrich
Qty/UOM
1
UOM
EA
Price: $1,315.38
List Price: $1,461.54

General description Toll like receptor adaptor molecule 1 (TICAM1) is ubiquitously expressed and possesses an N-terminal proline-rich domain, a TIR (Toll/interleukin-1 receptor) motif and a C-terminal proline-rich domain. The gene encoding this

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General description

Toll like receptor adaptor molecule 1 (TICAM1) is ubiquitously expressed and possesses an N-terminal proline-rich domain, a TIR (Toll/interleukin-1 receptor) motif and a C-terminal proline-rich domain. The gene encoding this protein is localized on human chromosome 19p13.3.

Immunogen

Synthetic peptide from human TICAM1 / TRIF.

Biochem/physiol Actions

Toll like receptor adaptor molecule 1 (TICAM1) plays a crucial role as an adaptor molecule and links toll-like receptor 3 (TLR3) to interferon-β (IFN-β) promoter activation. It is also involved in IFN-β production. TICAM-1 pathway has an essential role in host protection and innate immune responses against poliovirus (PV) infection. Mutations in the gene have been associated with the development of papillary thyroid cancer, follicular thyroid cancer and differentiated thyroid cancer.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide.

Shipping Information:

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UPC:
51282003
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
SAB2900288-50UG
Temperature Control Device:
Yes

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