General description
Tumor necrosis factor receptor 1 (TNFR1) belongs to the TNFR superfamily and is ubiquitously expressed. It comprises an extracellular domain with a cysteine-rich motif, a transmembrane segment, and an intracellular domain with a “death domain†motif. The TNFR1 gene is mapped to human chromosome 12p13.31.
Immunogen
The antiserum was produced against synthesized peptide derived from human TNF Receptor I.
Immunogen Range: 381-430
Application
Anti-TNF Receptor I antibody produced in rabbit has been used in immunostaining at a dilution of 1:200.
Biochem/physiol Actions
Tumor necrosis factor receptor 1 (TNFR1) is crucial for TNF for eliciting proinflammatory functions. Through its dead domain motif, TNFR1 interacts with the TNF receptor-associated death domain protein (TRADD). TNFR1 regulates cytotoxic signaling pathways. Blockage of TNFR1 in mouse model harboring respiratory syncytial virus (RSV) infection results in enhanced bronchoconstriction.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Shipping Information:
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- UPC:
- 41106614
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SAB4502988-100UG
- Temperature Control Device:
- Yes
