General description

Tranglutaminase-2 (also known as TGM2, TG2), is a widely expressed, multifunctional protein.

Application

Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit has been used in:

immunoblotting
immunoprecipitation
immunofluorescence
immunohistochemistry

Biochem/physiol Actions

Tranglutaminase-2 possesses enzymatic and GTPase activities, involved in multiple cell functions, including cell adhesion and cell signaling. TGM2 functions as a Ca²⁺-dependent enzyme capable of crosslinking both cytosolic and extracellular matrix proteins by catalyzing the formation of isopeptide bonds between lysine and glutamine residues. TGM2 is involved in the regulation of cell-matrix adhesion, cytoskeletal structure, cell migration and apoptosis. It is activated in response to tissue injury and plays an important role in wound healing and immune response. TGM2 is a major autoantigen in celiac disease and altered TGM2 expression or activity may be associated with Alzheimer′s disease, arteriosclerosis, type-2 diabetes and cancer metastasis in numerous forms of cancer.

Physical form

Solution in 0.01 M phosÂphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.