Anti-Tyrosine Hydroxylase Antibody (C15-1316-608)

General description

Tyrosine Hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.

Specificity

Cat. # AB9983 recognizes the C-terminus of Tyrosine Hydroxylase

Reactivity with other species has not been determined.

Immunogen

Epitope: C-terminus

Recombinant protein

Application

Anti-Tyrosine Hydroxylase Antibody detects level of Tyrosine Hydroxylase & has been published & validated for use in IH(P) & WB.

Immunohistochemistry: 1:100 working dilutions were used on rat and mouse brain (paraffin embedded tissue).

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Target description

~ 58 kDa

Physical form

Antigen Affinity Purified

Format: Purified

Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3

Storage and Stability

Stable for 1 year at 2-8ºC from date of receipt.

Analysis Note

Control
Rat Brain lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

biological source: rabbit. Quality Level: 100. antibody form: affinity isolated antibody. antibody product type: primary antibodies. clone: polyclonal. species reactivity: rat, mouse. technique(s): immunohistochemistry: suitable (paraffin), western blot: suitable. NCBI accession no.: NP_000351.2. UniProt accession no.: P07101. shipped in: wet ice. target post-translational modification: unmodified. Gene Information: mouse ... Th(21823)
rat ... Th(25085). Storage Class Code: 12 - Non Combustible Liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.