General description

Anti-ULK3 is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human ULK3, conjugated to KLH. Unc-51-like kinase 3 (ULK3) belongs to the ULK family of serine/threonine kinases. ULK3 is an autophagy related protein with an N-terminal kinase domain, which shows high similarity to those of ULK1 and ULK2. ULK3 localizes to the elongating isolation membrane upon autophagy activation.

Application

Anti-ULK3 antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Unc-51-like kinase 3 (ULK3) controls abscission timing in response to lagging chromosomes. Overexpression of ULK3 induces autophagy and senescence. ULK3 is also a positive regulator of the Hedgehog signalling pathway.

Physical form

Solution in 0.01 M phosÂphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.