ANTI-UVRAG ANTIBODY PRODUCED IN RABBIT AFFINITY ISOLATED ANTIBODY (C005B-474925)

General description

Ultraviolet irradiation resistance-associated gene (UVRAG) is an important autophagic tumor suppressor, encoded by the gene mapped to human chromosome 11q13.5. The encoded protein is characterized with four functional domains, such as proline-rich domain, a lipid-binding C2 domain, a beclin1-binding coiled-coil domain (CCD) and a C-terminal domain involved in centrosome integrity and DNA damage repair.

Immunogen

synthetic peptide corresponding to amino acids 665-678 of human UVRAG, conjugated to KLH. The corresponding sequence is identical in mouse.

Application

Anti-UVRAG antibody has been used in:

• immunoblotting
• western blotting
• immunofluorescence

Anti-UVRAG antibody produced in rabbit has been used:

• in western blotting
• in immunofluorescence

Biochem/physiol Actions

Ultraviolet irradiation resistance-associated gene (UVRAG) is implicated in the regulation of intracellular membrane trafficking, including autophagy and chromosomal stability. The encoded protein regulates apoptosis by suppressing the BCL2-associated X protein (Bax) activity. Mutation in the gene has been observed in various types of human cancers, including microsatellite unstable colon carcinomas.

Target description

UVRAG activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a prot

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

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