General description
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. (provided by RefSeq)
The vascular endothelial growth factor-C (VEGF-C) gene with seven exons is mapped to human chromosome 4q34.3. It is a member of the VEGF family of structurally related proteins. Members of the family contain a common VEGF homology domain. This domain forms the core region and contains a cystine knot motif with eight invariant cysteine residues. In adults, VEGF-C is mainly expressed in heart, placenta, ovary, small intestine and the thyroid gland, whereas in embryonic tissue, it is expressed in the perimetanephric, axillary and jugular areas.
Immunogen
VEGFC (ABM85407.1, 1 a.a. ~ 419 a.a) full-length human protein.
Sequence
MHLLGFFSVACSLLAAALLPGPREAPAAAAAFESGLDLSDAEPDAGEATAYASKDLEEQLRSVSSVDELMTVLYPEYWKMYKCQLRKGGWQHNREQANLNSRTEETIKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRRSLPATLPQCQAANKTCPTNYMWNNHICRCLAQEDFMFSSDAGDDSTDGFHDICGPNKELDEETCQCVCRAGLRPASCGPHKELDRNSCQCVCKNKLFPSQCGANREFDENTCQCVCKRTCPRNQPLNPGKCACECTESPQKCLLKGKKFHHQTCSCYRRPCTNRQKACEPGFSYSEEVCRCVPSYWKRPQMS
Biochem/physiol Actions
VEGF-C (vascular endothelial growth factor-C) has a role in lymphangiogenesis. It functions through the VEGF receptor-3 (VEGFR-3). Experimental studies have shown that VEGF-C is required for lymphatic endothelial cells to form sprouting capillaries. VEGF-C expression has been observed in breast cancer, prostatic cancer, gastric cancer, colon cancer and lung cancer.
Physical form
Solution in phosphate buffered saline, pH 7.4
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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- UPC:
- 51204100
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SAB1411757-50UG
- Temperature Control Device:
- Yes
