General description
Vacuolar protein sorting 34 (VPS34), also known as phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), is encoded by the gene mapped to human chromosome 18q12.3. The encoded protein belongs to the phosphoinositide (PI)-3-kinase family. VPS34 is widely expressed in all tissues of mammals.
Immunogen
synthetic peptide corresponding to amino acids 22-34 of human VPS34, conjugated to KLH via an added cysteine residue. The corresponding sequence is identical in mouse and rat.
Application
Anti-VPS34 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Vacuolar protein sorting 34 (VPS34) is a lipid kinase that phosphorylate phosphatidylinositol (PtdIns), to form phosphatidylinositol 3 phosphate (PtdIns3P). VPS34 plays a vital role in various intracellular trafficking events such as autophagy and phagosome formation. Thus, the inhibition of kinase activity of Vps34 might be considered as a potential therapeutic method for cancer treatment. VPS34 is also involved in internal vesicle formation within multivesicular endosomes, reverse transport of endosome to Golgi apparatus and membrane transport from the outer nuclear membrane towards the cell periphery. Mutation in the gene encoding VPS34 is associated with pathogenesis of schizophrenia. VPS34 plays an essential role in nutrient/amino acid induced activation of mechanistic target of rapamycin (mTOR) signaling in cultured cells and it also facilitates early embryogenesis and cell proliferation.
Target description
VPS34 is known to be involved in endocytosis and vesiculartrafficking.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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- UPC:
- 51411703
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- V9764-200UL
- Temperature Control Device:
- Yes
