General description
Effective concentration: 1-100 µM.
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain, and some cysteine proteases (IC50 ~500 ng/ml). Effective at concentrations of 1-100 µM.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Trypsin-like serine proteases
Product does not compete with ATP.
Reversible: no
Target IC50: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Other Notes
Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Umezawa, H. 1976. Methods Enzymol.55, 678.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51102811
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 178220-5MG
- CAS:
- 37682-72-7
