Amino Acid Sequence
Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 [Disulfide Bridges: 1-11, 3-15]
General description
Apamin, a bee venom is a polypeptide, that is made of 18 amino acids with two disulfide bridges.
Application
Apamin has been used in microbiological assays for the determination of antimicrobial activity of synthetic apamin and as a standard for MALDI (matrix-assisted laser desorption/ionization matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and electrospray ionisation mass spectrometry (ESI-MS) analysis.
Biochem/physiol Actions
Apamin is a neurotoxin which can pass the blood-brain barrier. In human, it might cause peripheral nerve dysfunction, mainly seen after bee stings.
The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
Other Notes
Lyophilized from 0.1% TFA in H2O
- UPC:
- 51144502
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- A9459-.5MG
- CAS:
- 24345-16-2
