Aphidicolin (C09-0713-064)

Aphidicolin is a tetracyclic diterpene antibiotic and DNA synthesis inhibitor isolated from Cephalosporium aphidicola. Aphidicolin is reported to specifically inhibit DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases. This compound blocks the cell cycle at early S phase and has been reported to be useful for synchronizing cell cycles in cultured eukaryotic cells. This compound is also noted to induce apoptosis in HeLa S3 cells after 18-24 hours of the cell cycle.A novel tetracyclic diterpene antibiotic and also a DNA synthesis inhibitor in eukaryotes. Specifications and Purity: 98%. MDL Number: MFCD00083214. Molecular Formula: C20H34O4. Molecular Weight: 338.48. PubChem CID: 457964. Isomeric SMILES: C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O. Beilstein Registry Number: 4689958.