APS-2-79 (C007B-325045)

Catalog No.: C007B-325045
Mfr. No.: A647721-100mg
Mfr. Name: Aladdin Scientific
Qty/UOM: 1
UOM: EA

Price: $518.18

List Price: $575.75

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Description
Specifications

APS-2-79 is a KSR -dependent MEK antagonist. APS-2-79 inhibits ATP biotin binding to KSR2 within the KSR2-MEK1 complexe with an IC 50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signalingIn VitroAPS-2-79 (5 μM) suppresses KSR-stimulated MEK and ERK phosphorylation in 293H cells. APS-2-79 (1 μM) enhances the efficacy of the clinical MEK inhibitor trametinib within cancer cell lines containing K-Ras mutationsMCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:KSR2 120 nM (IC 50 ) MEK1. Specification: 0.99 Molecular Formula: C23H21N3O3 Molecular Weight: 387.43 PubChem CID: 121499159

UPC:: 51202000
Condition:: New
Availability:: 8-12 weeks
Weight:: 1.06 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: A647721-100mg
CAS:: 2002381-25-9
Product Size:: 100mg

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