General description
A cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).
A cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
APT1
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Adibekian, A., et al. 2012. J. Am. Chem. Soc.134, 10345.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 415.79. Empirical Formula: C18H17ClF3N3O3. Assay: ≥. 98% (HPLC). Quality Level: 100. form: solid. potency: 840 . nM IC50. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, protect from light. color: white. solubility: DMSO: 50 . mg/mL. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 12352200
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 5316200001