Arbutamine

Arbutamine is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine stimulates cardiac β 1 -, tracheal β 2 -, and adiopocyte β 3 - adrenergic receptors. Arbutamine provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine can be used for cardiac stress agentIn VitroArbutamine (0.1-100 nM) increases heart contractile force and pD 2 value of 8.45. Arbutamine has the affinity constants (KA) value of 7.32 for cardiac β 1 -adrenergic receptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoArbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg). MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:β-adrenoceptor. Specification: ≥98.0% Molecular Formula: C18H23NO4 Molecular Weight: 317.38 PubChem CID: 60789 Isomeric SMILES: C1=CC(=CC=C1CCCCNC[C@@H](C2=CC(=C(C=C2)O)O)O)O