ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor ( AR ) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR -positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of 0.2-1 nAppearance:SolidIC50& Target:VHLIn Vitro:ARD-266 (Compound 11; 100 nM; 1-24 hours; LNCaP and VCaP cells) treatment effectively reduces the AR protein level within 3 h and achieves near-complete AR elimination with a 6 h treatment in the LNCaP cells. ARD-266 (Compound 11; 1-10000 nM; 24 hourBiological Activity:ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor ( AR ) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR -positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of 0.2-1 n. Specification: 0.99 Molecular Formula: C52H59ClN6O7 Molecular Weight: 915.51
- UPC:
- 51182438
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A658631-5mg
- Product Size:
- 5mg
