ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.In VitroKRAS G12C is recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRAS G12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP is restricted only to the GDP-bound state. This strategy proves feasible for inhibiting mutant KRAS in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:KRAS(G12C). Specification: 0.98 Molecular Formula: C21H17ClF2N4O2 Molecular Weight: 430.84
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A649218-50mg
- CAS:
- 1698055-86-5
- Product Size:
- 50mg
