Artemisone (C09-1103-150)

Artemisone (Artemifone) is a potent and semi-synthetic antimalarial , inhibits P. falciparum strains, with a mean IC 50 of 0.83 nM Artemisone is also a potent inhibitor of human CMV .In VitroArtemisone inhibits 3D7 and K1 P. falciparum , with IC 50 s of 0.88±0.59 and 1.23±0.64 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoArtemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED 50 of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration . Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:Plasmodium. Specifications and Purity: 10mM in DMSO. Molecular Formula: C19H31NO6S. Molecular Weight: 401.52.