AS1517499 (C09-0735-596)

InformationAS1517499 AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.TargetsSTAT6 (Cell-free assay) 21 nMIn vitroAS1517499 inhibit IL-4-induced Th2 differentiation of mouse spleen T cells, but has no influence on Th1 differentiation induced by IL-12. AS1517499 is able to prevent the IL-4-activated STAT6-mediated increase of the clonogenic potential of primary PCa cells. At a dose of 300\u2009nM, AS1517499 decreases the clonogenic potential of primary basal PCa cells.In vivoIn vivo treatment with AS1517499 ameliorates the antigen-induced bronchial smooth muscle (BSM) hyperresponsiveness by inhibiting the RhoA up-regulation in BSMs and, at least in part, by reducing the IL-13 production in the airways in mice. AS1517499 reduces preventive effects of apoptotic cell instillation on bleomycin-induced lung fibrosis by suppressing PPARγ.Cell Research(from reference)Cell lines：Normal human BSM cells Concentrations：100 nM Incubation Time：30 min. Specifications and Purity: 97%. Molecular Formula: C20H20ClN5O2. Molecular Weight: 397.86. PubChem CID: 10340781. Isomeric SMILES: C1=CC=C(C=C1)CNC2=NC(=NC=C2C(=O)N)NCCC3=CC(=C(C=C3)O)Cl. Related Document: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A414116-SCI_32f43367cb5be5cf25a7a6079c1e0844.pdf