Auristatin F (C09-1102-462)

Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation. Auristatin F can be used in antibody-drug conjugates (ADC)In VitroAuristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin used in antibody-drug conjugates. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoAuristatin F (5 mg/kg; i.v.; male Sprague-Dawley rats) has C max of 8276.76 ng/mL. The AUC last is 65661.30 min*ng/mL, and the clearance (CL) is 77.33 mL/min/kg, which is above the hepatic blood flow in the rat. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley ratsDosage: 5 mg/kg Administration: Intravenous injection Result: 1.19 Parameter Dose (i.v.) mg/kg 5 C max (ng/mL) 8276.76 AUC last (min*ng/mL) 62661.30 CL (mL/min/ng) 77.33 Vss (mL/Kg) 1057.13Form:SolidIC50& Target:Microtubule. Specification: 0.99 Molecular Formula: C40H67N5O8 Molecular Weight: 746 PubChem CID: 67472795 Isomeric SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C