AZ12672857 is an orally active inhibitor of EphB4 ( IC 50 =1.3 nM) and Src kinases . AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC 50 =2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC 50 =9 nM)In VitroAZ12672857 shows only modest inhibition of CYP P450 (IC 50 =5 μM against 2C9 and 3A4, >10 μM against 1A4, 2D6 and 2C19). AZ12672857 inhibits p-KDR in HUVEC with an IC 50 of 240 nM and inhibits p-PDGFR-βin MG63 cell line with an IC 50 of 58 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Src. Specification: 0.98 Molecular Formula: C26H30N8O2 Molecular Weight: 486.57 PubChem CID: 49831162 Isomeric SMILES: CN(C1=NC(=NC=C1)NC2=CC(=CC(=C2)N3CCOCC3)N4CCOCC4)C5=CC=CC6=C5C=NN6
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A648653-50mg
- CAS:
- 945396-55-4
- Product Size:
- 50mg
