AZ32 (C005B-310505)

Catalog No.: C005B-310505
Mfr. No.: SML2551-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $952.39

List Price: $1,058.21

Biochem/physiol Actions AZ32 is an orally active, potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitor (IC 50 <:6.2 nM: DNA-PK &: PI3Ka IC 50 =4.

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Description
Specifications

Biochem/physiol Actions

AZ32 is an orally active, potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitor (IC₅₀ <6.2 nM; DNA-PK & PI3Ka IC₅₀ =4.6 μM, hERG IC₅₀ = 17.6 μM) with good aqueous solubility (24 μM) and blood-brain barrier (BBB) permeability in mice (free brain/plasma ratio = 0.26; 200 mg/kg p.o.). AZ32 exhibits radiosensitizing efficacy in human & murine glioma cultures by blocking radiation-induced DNA damage response (ATM pS1981 IC₅₀ = 310 nM; 100% blockage of KAP1 pS824 & p53 pS15 at 300 nM; T98G cells). AZ32 (200 mg/kg/day p.o.) improves whole-head irradiation treatment survival rate among mice with brain GL261 tumors or NCI-H2228 NSCLC metastases in vivo.

UPC:: 51441900
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2551-25MG
CAS:: 2288709-96-4

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