AZD1940 (C09-1102-186)

AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pK i values of 7.93 and 9.06 for human CB1R and CB2R , respectively. AZD1940 shows a robust analgesia actionIn VitroAZD1940 binds with high affinity to human, rat and mouse CB1 and CB2 receptors and displays full agonism at both receptors in all three species . MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoWhen given orally to rats, AZD1940 produces a robust analgesia in different models of inflammatory and neuropathic pain. For AZD1940, low brain uptake at analgesic doses has been demonstrated in both rats and primates . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:hCB1-R 7.93 (pKi) hCB2-R 9.06 (pKi). Specifications and Purity: 99%. Molecular Formula: C20H29F2N3O2S. Molecular Weight: 413.52. PubChem CID: 11675994. Isomeric SMILES: CCS(=O)(=O)NC1=CC2=C(C=C1)N(C(=N2)C(C)(C)C)CC3CCC(CC3)(F)F.