Bafilomycin A1 from Streptomyces griseus (C15-1288-627)

Catalog No.: C15-1288-627
Manufacturer No.: B1793-10UG
Manufacturer Name: Sigma-Aldrich
Quantity: 10
Unit of Measure: UG

Price: $385.71

List Price: $428.57

Chemical structure: macrolide Application Bafilomycin A1 has been used: as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytes as a vacuolar-type H + -ATPase inhibitor to study its effects on the cell viability,

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Description
Specifications

General description

Chemical structure: macrolide

Application

Bafilomycin A1 has been used:

as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytes
as a vacuolar-type H⁺ -ATPase inhibitor to study its effects on the cell viability, percentage of PI-positive cells, and glucose-stimulated insulin secretion (GSIS) in mice INS-1 cells
as a vacuolar-type H⁺ -ATPase inhibitor to study its effects on tau degradation in human SH-SY5Y cells

Biochem/physiol Actions

A specific inhibitor of vacuolar type H⁺-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.

Bafilomycin A1 inhibits autophagosome-lysosome fusion and autolysosome acidification, the steps involved in the autophagic process that is required for maintaining functional autophagic flux and cellular homeostasis.

UPC:: 51281673
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: B1793-10UG

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