BAY-6672 HYDROCHLORIDE HYDRATE (C005B-309322)

Catalog No.: C005B-309322
Mfr. No.: SML3232-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $258.15

List Price: $286.83

Biochem/physiol Actions BAY-6672 is an orally active, potent and selective prostaglandin F receptor (FP-R, PTGFR) antagonist (IC50 = 11 nM against 3 nM PGF2?-induced calcium flux in hFP-R Chem-1 cells: IC50 = 12/18 nM against 3 μ:M

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Biochem/physiol Actions

BAY-6672 is an orally active, potent and selective prostaglandin F receptor (FP-R, PTGFR) antagonist (IC50 = 11 nM against 3 nM PGF2?-induced calcium flux in hFP-R Chem-1 cells; IC50 = 12/18 nM against 3 μM PGF2α-induced KC/MCP1 production in NIH-3T3) with >420-fold selectivity over human prostaglandin receptors (PG-Rs) EP1-4, DP, CRTH2 and IP. BAY-6672 shows in vivo efficacy in a murine lung fibrosis model (3, 10, 30 mg/kg b.i.d. p.o.).

UPC:: 51183407
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3232-5MG
CAS:: 2640870-12-6

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