BAY-899 (C09-1113-460)

BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levelsIn VivoBAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats . BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t 1/2 of 11 hours and 12 hours for iv and po. And the C max is 0.97 kg/L and 0.24 kg/L for iv and po . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Intact female rats Dosage: 12.5 mg/kg Administration: Oral; for 8 days Result: Showed an efficiency to reduce serum estradiol levels. Animal Model: Female and male Wistar rats Dosage: 0.5 mg/kg of iv or 2 mg/kg of po Administration: Iv or po Result: Has t 1/2 s of 11 hours and 12 hours for iv and po. And the C max s are 0.97 kg/L and 0.24 kg/L for iv and po.Form:SolidIC50& Target:IC50: 185 nM (hLH) and 46nM (rLH). Specification: 0.99 Molecular Formula: C25H19F2N5O2 Molecular Weight: 459.45 PubChem CID: 139600336 Isomeric SMILES: C1CN([C@H](C2=C1N=CC=C2)C3=CC=C(C=C3)F)C(=O)NC4=CN=C(N=C4)OC5=CC=C(C=C5)F