BAY-985 (C09-0785-955)

InformationBAY-985 is a potent and highly selectiveTBK1/IKKεinhibitor. BAY-985 shows high potency towardTBK1(IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) andIKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an antiproliferative effect on SK-MEL-2 cells (IC50 = 900 nM).TargetsTBK1 (in low ATP assay); IKKε (Cell-free assay); TBK1 (in high ATP assay); pIRF3 (Cell-free assay) 2 nM ;2 nM; 30 nM; 74 nMIn vitroBAY-985 is a potent and highly selective TBK1/IKKε inhibitor that inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2.In vivoBAY-985 shows only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.Cell Research(from reference)Cell lines：ACHN, SK-MEL-2, MDA-MB231 cells Concentrations：100 nM Incubation Time：96 h. Specification: 0.98 Molecular Formula: C27H30F3N9O Molecular Weight: 553.58 PubChem CID: 145925685 Isomeric SMILES: C[C@H](C1=CC(=NC=C1)NC2=NC3=C(N2)C=C(C=C3)C4=CC(=NC=N4)N(C)C)N5CCN(CC5)C(=O)CC(F)(F)F