A Cl-amidine derivative with greater cellular potency against PAD4 activity (EC50 = 8.8 µM, vs. >200 µM for Cl-amidine) and a significantly longer in vivo half-life (1.75 h, vs. ~15 min for Cl-amidine); effective in vivo, improving endothelial function while downregulating the expression of type I interferon-regulated genes in MRL/lpr mice.
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- UPC:
- 51321806
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- 17079-1