BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitorIn VivoTreatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MRL/lpr mice . Dosage: 1 mg/kg. Administration: Subcutaneous injection daily from 8 to 14 weeks of age. Result: Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs.Form:SolidIC50& Target:PAD. Specification: 0.99 Molecular Formula: C26H27Cl2N5O Molecular Weight: 496.43
- UPC:
- 12352129
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B650942-10mg
- CAS:
- 2436747-41-8
- Product Size:
- 10mg
