General description
A boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.
Biochem/physiol Actions
Cell permeable: no
Primary Target
arginase 1, arginase 2
Product does not compete with ATP.
Reversible: no
Target Ki: 310 nM for human recombinant type II arginase, pH 7.5
Packaging
Packaged under inert gas
Warning
Toxicity: Harmful (C)
Reconstitution
Following reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.
Other Notes
Colleluori, D.M., and Ash, D.E. 2001. Biochemistry40, 9356.
Kim, N.N., et al. 2001. Biochemistry40, 2678.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51282906
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 197900-5MG
