beta Amyloid 1-42, abeta, ultra pure, HFIP, recombinant human (C15-1318-356)

General description

β Amyloid 1-42 is a derivative of integral membrane-bound amyloid precursor protein. It is the most important alloform of the Alzheimer′s peptide.

Application

β Amyloid 1-42, aβ, ultra-pure, HFIP, recombinant human has been used:

• to study its effect on the activity of mitochondrial BKCa (mitoBKCa) channels in human astrocytoma cells through patch-clamp technique
• to study its effect on alteration in protein levels of dystrophic neurites (DNs) forming proteins in mouse neuroblastoma cells
• to induce Alzheimer′s disease in a rat model for experimental studies

Biochem/physiol Actions

β Amyloid 1-42 causes neurotoxicity and is implicated in the pathogenesis of Alzheimer′s disease (AD). β Amyloid (βA) acts as a ligand for several receptors and other molecules involved in complex trafficking pathways in tissues and blood-brain barriers. βA along with amylin elevates cyclic adenosine monophosphate (cAMP) and Ca²⁺ in turn activates multiple signaling pathway mediators like mitogen-activated protein kinase (MAPK), protein kinase A/B, and cFOS. It acts as the main source of AD-associated neuroinflammation.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

biological source: human. Quality Level: 100. Assay: >. 97.0%. form: powder. manufacturer/tradename: Chemicon^®. . NCBI accession no.: NM_000484.2, NM_201413.1, NM_201414.1. UniProt accession no.: P05067. Gene Information: human ... APP(351). Storage Class Code: 13 - Non Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.