BF-168 (C09-1113-795)

BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a K i of 6.4 nM for Aβ1-42 .In VitroBF-168, a styrylbenzoxazole derivative, is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques, with a K i of 6.4 nM for Aβ1-42. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIntravenous injection of BF-168 in PS1/APP and APP23 transgenic mice result in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18 F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t 1/2 =24.7 min) after intravenous administration in normal mice. Furthermore, autoradiograms of brain sections from APP23 transgenic mice at 180 min after intravenous injection of [ 18 F]BF-168 shows selective labeling of brain amyloid deposits with little nonspecific binding . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Ki: 6.4 nM (Aβ1-42). Specification: 0.99 Molecular Formula: C18H17FN2O2 Molecular Weight: 312.34 PubChem CID: 10244995 Isomeric SMILES: CNC1=CC=C(C=C1)/C=C/C2=NC3=C(O2)C=C(C=C3)OCCF