BIBB 515 is a selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) with an ED|50|value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. Total cholesterol was reduced by 19% in normalipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days. OSC is an important enzyme in the biosynthesis of animal, fungal and plant sterols. OSC catalyzes the conversion of (3S)-2,3-oxidosqualene to lanosterol, a precursor to cholesterol, in fungi and mammals. Specification: ≥98% Molecular Formula: C22H21ClN2O2 Molecular Weight: 380.9 PubChem CID: 501398 Isomeric SMILES: C1CN(CCC1=CC2=CC=C(C=C2)C3=NCCO3)C(=O)C4=CC=C(C=C4)Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B340882-SCI_778b0f213ecb05404a7a591e0dba87f2.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B340882-10mg
- CAS:
- 156635-05-1
- Product Size:
- 10mg
- Hazard Statement Codes:
- H335
- Precautionary Statement Codes:
- P261:P271
