General description
Mouse BID cleaved with caspase-8 generates the amino-terminal fragment (amino acids 1-59, 7 kDa) and the carboxy-terminal fragment (amino acids 60-195, 15 kDa). On size exclusion chromatography cleaved BID elutes at 27 kDa indicating that the fragments remain associated.
Biochem/physiol Actions
Caspase-8-cleaved BID relocates from the cytosol to the outer mitochondrial membrane where its interaction with Bak alters mitochondrial membrane permeability.
Physical form
0.2 μm filtered solution in 25 mM HEPES, pH 7.5, and 0.1 M KCl.
Analysis Note
Measured by its ability to induce cytochrome c release from isolated mouse liver mitochondria.
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- UPC:
- 41116134
- Condition:
- New
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- Weight:
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- MPN:
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- Temperature Control Device:
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