An orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM) that inhibits ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM); efficacious in several xenograft tumor models in mice, including those bearing K-Ras or B-Raf mutations, as well as in clinical studies using patients with N-Ras melanoma, non-small cell lung cancer, or biliary tract cancer.
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- UPC:
- 51442415
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 16996-5
- CAS:
- 606143-89-9
- Model Number:
- C816E61
- Temperature Control Device:
- Yes
