BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor ( K d <10 pM). BIO5192 hydrate selectively binds to α4β1 ( IC 50 =1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine heAppearance:SolidIC50& Target:α4β1 1.8 nM (IC 50 ) α9β1 138 nM (IC 50 ) α2β1 1053 nM (IC 50 ) α4β7 >500 nM (IC 50 )In Vivo:The combination of BIO5192 hydrate (1mg/kg; i.v.) and Plerixafor (5mg/kg; s.c.) exert an additive effect on progenitor mobilization. BIO5192 hydrate (30mg/kg; s.c; bid; during days 5 through 14) delays paralysis associated with EAE (experimental aBiological Activity:BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor ( K d <10 pM). BIO5192 hydrate selectively binds to α4β1 ( IC 50 =1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine he. Specification: 0.99 Molecular Formula: C38H46Cl2N6O8S.1/2H2O Molecular Weight: 826.79
- UPC:
- 51162743
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B659154-5mg
- Product Size:
- 5mg
