Antagonists

[1R-(2-endo,3-exo)]-3-Hydroxy-4,7,7-trimethylbicyclo[2.2.

A cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo- p -dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in

A cell-permeable purine compound that acts as a high affinity (IC 50 = 40 nM against [125I]-N3Br2DD binding to human AhR) AhR antagonist (IC 50 = 127 nM against 3 nM TCDD-induced luciferase reporter activity in HepG2 cultures), while exhibiting

A cell-permeable purine compound that acts as a high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC 50 = 62 nM in mouse liver cytosol expressing humanized AhR) and lacks any agonist activity even at higher doses. Reportedly binds with high

Biotin-(ring-6,6-d 2 ), an isotope-labeled analog of biotin, is also known as vitamin H (vitamin B 7 ). It is a water-soluble vitamin B essentially involved in the synthesis of fatty acids and in gluconeogenesis.

Biotin-(ring-6,6-d 2 ), an isotope-labeled analog of biotin, is also known as vitamin H (vitamin B 7 ). It is a water-soluble vitamin B essentially involved in the synthesis of fatty acids and in gluconeogenesis.

Biotin is a water-soluble vitamin B which is also known as vitamin B7. It is involved in the synthesis of fatty acids and gluconeogenesis.

An orally available, blood-brain barrier permeant piperidinylbutanamide compound that acts as a highly potent, selective, non-competitive and allosteric antagonist of C5a receptor (C5aR). Shown to effectively block C5a-induced human PMN migration

A cis -diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC 50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca +2 flux and chemotaxis (IC 50 = 18 and 1 nM, respectively), while showing much less

Other Notes Please note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of rare and unique chemicals. Sigma-Aldrich does not collect analytical data for this product.

An exocyclic cysteine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat.

A triazolyl-thiomorpholinyl-methanone compound that acts as a fibroblast growth factor-inducible 14 (Fn14) antagonist via direct affinity interaction ( K D = 7.12 &#181M) and competes against TNF-like Weak Inducer of Apoptosis (TWEAK)